Abstract

Purge-assisted headspace solid-phase micro-extraction (PA/HS-SPME) was proposed for the determination of dimethyl fumarate (DMF) extracted from finished leather. Samples were extracted from solvent by Accelerated Solvent Extractor (ASE), concentrated and purified with PA/HS-SPME, analyzed by gas chromatography-mass-spectrometry (GC-MS), and quantified against external standards. The parameters of PA/HS-SPME, such as temperature and time, were studied. Under the optimal conditions, the linearity for DMF was over the concentration range of 5-1000ng/ml; the detection limit was 1ng/ml; the relative standard deviation (n=6) was 9.94% at 100ng/ml. The recoveries were in the range of 66.8-91.5%. This eco-friendly method was applied to the determination of DMF in leather samples satisfactorily. The proposed PA/HS-SPME method opens new avenues for the determination of DMF in leather samples.